Comment on a Recent Article Titled “Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts”

In a recent issue of JBMR, Colaianni and colleagues reported the relationship circulating irisin levels, myokine synthesized from skeletal muscle, with bone muscle parameters in sample older adults.(1) They showed that FNDC5 expression, an precursor, biopsies positively correlated osteocalcin mRNA biopsies, suggesting connection between these tissues. Interestingly, treatment decreased p21 senescence marker, osteoblasts vitro. These findings may be guide for novel therapeutic approaches to delaying age-related atrophy loss. However, few points are worth discussing. The authors not have accounted several factors could influence their results, including chronic diseases some selected drugs. prevalence conditions increases after age 60 years, many people develop more than one disease. A cross-sectional study 740 participants association serum adiposity, glucose tolerance, insulin resistance middle-aged individuals.(2) same study, patients diabetes mellitus (DM) had lower levels those without DM.(2) Correspondingly, concentrations significantly among DM cohort adults years.(3) On other hand, experimental studies bolus intravenous administration arterial blood pressure by reducing vascular endothelial dysfunction via upregulation NO synthesis activating AMPK-Akt-eNOS pathway.(4, 5) Lower were found associated high systolic diastolic preeclampsia.(6) Besides, cardiac muscles important source synthesis, change heart function alter production this protein.(7) Many individuals prescribed drugs manage diseases. Metformin therapy is first-line agent individuals. interventional polycystic ovary syndrome, 3 months metformin improved resistance.(8) Lowering amlodipine valsartan increased untreated essential hypertension.(9) An animal statin muscle.(10) I would like ask whether they provide data on population's comorbidities medication mellitus, hypertension, hyperlipidemia. Inclusion new statistical analysis help make results stronger. New raise importance research, which aimed explore role senescence.